The International Conference on Public Health in Africa (CPHIA) 2022 will provide a unique platform for African researchers, policymakers, and stakeholders to come together and share perspectives and research findings in public health while ushering in a new era of strengthened scientific collaboration and innovation across the continent. Building on CPHIA 2021, this year’s conference will also serve as a catalyst to build more resilient health systems that allow African countries to better prepare for and manage emerging health threats while also addressing long-standing infectious diseases.