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Like many countries in sub-Saharan Africa, Ghana faces health worker shortages, limiting the country’s likelihood of meeting the Millennium Development Goals. Working together with the stakeholders and partners that make up the Ghanaian health care system, CapacityPlus supported the revitalization of the Ghana Health Workforce Observatory to address key human resources for health issues. This case study discusses the steps taken to revitalize the observatory through the application of Guidelines for Forming and Sustaining Human Resources for Health Stakeholder Leadership Groups. Success factors that contributed to the observatory’s revitalization are highlighted, along with challenges, lessons learned, and recommendations.